Introduced in the TV series You Can't Do That On Television, slime quickly became the symbol of Nickelodeon's theme of messiness. Especially popular was green slime, which was primarily used in many of Nick's shows. As times changed, messiness was phased out, and thus the slime. The Kids Choice Awards are still held at Slime Island at Nickelodeon Studios. Slime was used in merchandising along with the similar product known as gak. Slime is nontoxic, and some celebrities and audience members have even eaten some of it after being slimed.
- When Double Dare 2000 was advertised, the promotion included "The slime is prime. The gak is back.".